JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE
Online ISSN : 1349-7421
Print ISSN : 0468-2513
ISSN-L : 0468-2513
ORIGINALS
Usefulness of NS5 Antibody Measurement in Recombinant Immunoblot Assay (RIBA) as a Clinical Test for Confirmation of Asymptomatic HCV Infection
Yukihito MINATONaoko MOCHIZUKIKeiji KOSHIBUKouji HATTORITatsuo SHIIGAI
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JOURNAL FREE ACCESS

2005 Volume 54 Issue 4 Pages 640-643

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Abstract

  Using RIBA NS5 antibody was measured in 31 HCV RNA positive serotype 1 patients, and the serum levels of ALT were monitored for an average of three years. As a result, 22 asymptomatic HCV carriers (group A) were found to be NS5 antibody negative (-) and nine to be NS5 antibody positive (4+). By contrast, in 25 patients with chronic inactive hepatitis C (group B), three patients were NS5 antibody negative (-), and 22 patients were NS5 antibody positive (4+), indicating a significant difference between the two groups (p<0.01 chi square test).
  Furthermore, in group A, 22 NS5 antibody (-) patients (group I) maintained normal serum levels of ALT significantly longer than the 9 NS5 antibody (4+) patients (group II) (p<0.01, Kaplan-Meier Method). Therefore, the measurement of NS5 antibody of RIBA was clinically useful in identifing asymptomatic (HCVRNA positive, serotype 1) HCV carriers.

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© 2005 THE JAPANESE ASSOCIATION OF RURAL MEDICINE
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