1980 年 29 巻 4 号 p. 672-677
Based on previous anther's obsarbations of pseudocholinesterase (PCE) activity correlated with total cholesterol, fluctuation of this enzyme was epidemiologically studied in connection with changes of serum lipids on 225 sprayers of pesticides in citrut fruit area, and results are as follows;
1. PCE activity was slightly correlated with serum triglyceride (γ=0.277) and total cholesterol (γ=0.431) in females but not correlated in males.
2. PCE activity was significantly higher (P<0.05) in hyperlipemic subjects than normolipemic, and obviously higher (P<0.001) in hyperlipemic over weight subjects than hyperlipemic normal weight.
3. The enzyme activity was significantly higher (P<0.05) in hypertriglyceridemic subjects than in normolipemic, and highest (P<0.01) in subjects with hypertriglyceridemia and hypercholesteremia.
4. Serum triglyceride values in males and serum cholesterol values in females were obviously higher (P<0.05) in the high level group of PCE activity than in the low level group.
5. PCE activity was exhibited a tendency of elevation in hypertensive females than in normal blood pressure, and slightly correlated with systoric blood pressure (γ=0.286) and diastoric blood pressure (γ=0.358) in females.
6. PCE activity was found to be lower (P<0.05) in arterioslerotic subjects than nonsclerotic subjects with ocular funduscopic findings.
These epidemiological findings suggested that PCE might play a role in lipid metabolism and reduction of this enzyme might cause disturbances of lipid metabolism.