肺胞内圧の肺循環動態に与える影響に関する臨床的研究

特に肺疾患々者の肺動脈拡張期圧に関して

抄録

The effect of mean alveolar pressure (Pal) and pleural pressure (Ppl) on pulmonary hemodynamics were studied in 19 pulmonary patients. The change of pulmonary arterial diastolic pressure (P_PAd) had a linear correlation with those of Pal and Ppl in each patient. In 8 patients with pulmonary hypertension, the values of ΔP_PAd/ΔPal, as well as ΔP_PAd/ΔPpl, were significantly higher than those in 11 patients without pulmonary hypertension. Furthermore, the pulmonary arterial pressure (P_PA) in the group with higher ΔP_PAd/ΔPal (≥0.86) was significantly higher than that in the group with lower ΔP_PAd/ΔPal (<0.86). On the other hand, the pulmonary arterial compliance (C) in the former group was significantly lower than that in the latter group.
These data suggest that the change of P_PAd under the influence of Pal or Ppl relate with the organic change of pulmonary vessels, indicated as P_PA, C.