The Japanese journal of thoracic diseases
Online ISSN : 1883-471X
Print ISSN : 0301-1542
ISSN-L : 0301-1542
Pneumocrystis carinii Pneumonia Associated with High Levels of Serum KL-6
Ryohko KawakamiKazuhiro KikuchiJun KobayashiYasuhiro ShibuyaShinichi HagiwaraNaohiko SakuMitsugu HironakaTakeshi FujiiYoshizoh Chiba[in Japanese]
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1996 Volume 34 Issue 12 Pages 1420-1426

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Abstract

In May 1995, a 52-year-old man complaining of fever and dyspnea was admitted to a hospital. Based on clinical and radiographic findings, hypersensititivity pneumonitis was suspected. Steroid pulse therapy was unsuccessful, and he was then transferred to our hospital. A chest X-ray film showed bilateral ground-glass shadows and a high-resolution CT scan showed cystic air spaces. The number of CD4-positive lymphocytes in peripheral blood was very low. A test for anti-human immunodeficiency virus antibody was positive and Pneumocystic carinii was found in bronchoalveolar lavage fluid. The acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia were diagnosed. In this patient, the level of serum KL-6, a new marker of interstitial pneumonitis, was very high, and KL-6 was expressed on type II pneumocytes. The level of serum KL-6 may be useful as a marker of the activity of Pneumocystis carinii pneumonia.

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© by The Japanese Respiratory Society
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