2017 Volume 37 Issue 2 Pages 193-200
Aging is the biggest risk factor for postoperative cognitive dysfunction(POCD). With aging, the number of surgeries in elderly people increases, so POCD may become a major social issue. The subject method of evaluating clinical studies of POCD are not yet standardized, and the elucidation of POCD has not advanced. On the other hand, animal studies strongly suggest that neuroinflammation is associated with the onset of POCD. Perioperative care to inhibit neuroinflammation is expected to play a key role in future prophylactic strategies to prevent POCD.