What You Need to Know about Sugammadex-induced Anaphylaxis

Abstract

Sugammadex is an antagonist of aminosteroid muscle relaxants. In Japan, the usage of sugammadex has expanded since its release in 2010 due to its reliable antagonistic action. However, there have been several reports of anaphylaxis caused by sugammadex. Our recent study found the incidence of anaphylaxis due to sugammadex to be approximately 1 in 5,000 cases. Although clinical symptoms associated with sugammadex-induced anaphylaxis do not differ from those caused by other drugs, anesthesiologists should always be aware that critical symptoms such as severe bronchospasm may be observed even after extubation. Since the mechanisms of anaphylaxis due to sugammadex remains unclear, future research is needed.