子宮頸部double cancerの細胞診所見

抄録

A case of double cancer of the uterine cervix wasreported, which we diagnosed cytologically with thevaginal smear from the patient of uterine cervicalcancer (Stage IIb).
In cytological observation of the vaginal smear, we noticed both a group of well-differentiated malignantcells of squamous origin and a malignant cellsof adenomatous nature, which were independent eachother in their arrangement. We considered that thepresent case was obviously different from adenoacanthoma, since the latter is known to be free ofa well-differentiated malignant cells of squamousorigin and is also known to include mixed arrangementof those different types of malignant cells.The cytological findings of the present case, therefore, indicates a double cancer of uterine cervix.
Punch biopsy of the uterine cervix (before operation) as well as pathological examination by serialsectioning of the same tissue (after operation) werecarried out. Those histological studies also provedthe coexistence of two different types of malignantcells; i.e., a part of well-differentiated squamous cellcarcinoma and one of adenocarcinoma. The specimensshowed obvious features of so-called ‘collisions-tumor’ of two different nature of malignant cells, whichnever intermingled,
The same findings were again noticed in the metastaticlymph nodes.