1972 年 11 巻 2 号 p. 115-125
It was discussed last year about “cytologicalcriteria of breast cancer for the purpose of massscreening” in the paper vol.10.1. pp.9-22 of thisJournal. Main points of previous paper were as follows; 1) Over 20μ of nuclear diameter. 2) Over 5μ of nucleolar diameter. 3) Over 5 nucleoli in onenucleus. 4) The largest nuclear diameter have 2times as the smallest one in one cell cluster. (Marked anisokaryosis.) These 4 findings mean positivecytology.
In this report, it is discussed that how many casescome under these criterias.
50 cases of breast cancer (Papillo-tubular carcinoma 28 cases, Medullary tubular carcinoma 11 cases, Scirrhous carcinoma 10 cases and 1 case of adenoidcystic carcinoma.) are examined.
Aspiration smear preparations are stained by MayGiemsa method, and tissue preparation of operationmaterials are stained by H.E. method.
Results are as follows.
1) Smear preparation which keep the cells ofover 20μ nuclear diameter are found in 41cases of all cases. (80%)
2) Smear preparation which keep the cells ofover 5μ nucleolar diameter are found in 25cases. (50%)
3) Smear preparation which keep the cells ofnumerous (over 5) nucleoli found in 18 cases. (36%)
4) Anisokaryosis over 2 times in one cell clusterwhich keep the clear chromatin structure found in 34 cases. (68%)
So it may be clear that the first criteria for massscreening is large nucleus (over 20μ). 80% of allcases of breast cancer may be checked by this finding. Another cases (20%) may be diagnosed by otherfindines.
But a few cases of non-malignant disease havelarge nucleus (over 20μ)., Benign cells with largenucleus have well stained wide cytoplasma and scattered solitary not clumped.