Cytologic examination on 1715 cases (52 cases ofcancer and 1663 cases of non-cancer) was executedin Miyagiken Seijinbyo Center (Adult Disease Center of Miyagi Prefecture).
Cytologic examination of nipple discharge wascarried out on 1099 cases. The results were positivein 2 cases, suspicious in 1 case and negative in 11 cases of all 14 cases of cancer. Of all 1085 cases ofnon-cancer were 1084 cases negative, one case suspicious and no positive.
The results of aspiration smear cytology on 740 cases were positive in 35 cases, suspicious in 3 casesand negative in 7 cases of 45 cases of cancer andnegative 693 cases, suspicious in 2 cases and nopositive of 695 cases of non-cancer.
The causes of the “false negative” in aspirationsmear cytology are chiefly due to the unsuited sitefor puncture and secondly due to the misjudgementof cytology. The “false positive” is evidently dueto misjudged cytology.
Careful regard should be paid to following fiveitems as the diagnostic criteria for the malignantcells in aspiration smear cytology.
1. decrease of intercellular connection.
2. excessively and asymmetrically piled figureof cells and nuclei.
3. fusion of cells, the cellular inclusion andnuclear deformation.
4. enlarged cells (especially with the increasednuclear cytoplasmic ratio).
5. some dense distribution of distinctly granulated chromatin.
