日本臨床細胞学会雑誌
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
神経芽細胞腫とウイルムス腫瘍の細胞所見
小児後腹膜腫瘍の鑑別のために
柴田 偉雄小林 康夫近藤 明人矢吹 光子
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ジャーナル フリー

1972 年 11 巻 2 号 p. 95-100

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Neuroblastomas of suprarenal glands and Wilms'tumors are relatively common malignant tumorsin children. These tumors often grow into largeretroperitoneal tumors and their clinical diagnosticdifferentiation is rather difficult. Diagnostic cytologymay be effective for differential diagnosis on thesecases. The cytological examinations of aspirationbiopsy smears and tuch smears prepared from 3patients with neuroblastomas and 2 Wilms' tumorswere performed, and the following results fordifferential cytodiagnosis were obtained.
1. Epithelial cell clusters were much more frequently found in Wilms' tumors than in neuroblastomas.
2. Cytoplasms of some Wilms' tumor cells withepithelial arrangement were stained deep blue bythe may-Giemsa's method.
3. Neuroblastoma cells had marked anisocytosisand were smaller in size than Wilmis' tumor cells.
4. Nuclei of neuroblastoma cells were most frequently composed of densely distributed chromatinwith fine or coarse granular structure, and those of Wilms' tumor cells were composed of moderatelyincreased chromatin with fine reticular or granularpattern.
5. Nucleoli of neurolastoma cells were inrregularin shape, small in size and 2 to 4 in number. Tooseof Wilms' tumor cells were round, small and 1 or2 in namber, or hardly observable.
By the cytological findings described above, it was possible to distinguisn neuroblastomas from Wilms'tumors in diagnostic cytology.

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