子宮体部中胚葉性混合腫瘍の細胞学的ならびに電子顕微鏡的研究

抄録

A case of malignant mixed mesodermal tumor of the corpus uteri was studied by electron microscopy and compared with cytological findings.
The clinical course of this case was specific; the patient had previous irradiation before 35 years. A history of previous irradiation in a patient with mixed mesodermal tumor suggests an extremely poor prognosis. A time of servival was 4.5 months after operation.
The diagnosis of fibrosarcoma of the corpus uteri was made by cytology preoperatively, but the findings of adenocarcinoma was not observed cytologically. The cytological findings of the fibrosarcoma was explained in details.
Histologically, the carcinomatous element was composed of papillary adenocarcinoma and the sarcomatous element was composed of fibrosarcoma, leiomyosarcoma and heterologous element (chondrosarcoma, osteosarcoma). The ultrastructural study on the mixed mesodermal tumor of the corpus uteri is extremely rare, in our study there were observed four types of malignant cells, that is, adenocarcinoma, fibrosarcoma, leiomyosarcoma and osteosarcoma.
The problem of the histogenesis of this tumor is one which still remains to be solved. The rese mbrance was seen on the each sarcomatous elements ultrastructurally, but no transitions from carcinoma cells to these types was noted.
In view of these findings, it is suggested that the carcinomatous element are originated from Miillerian epithelium and the sarcomatous element appeared to be originated simultaneously from the mesenchyme formed from surrounding Mallerian duct.