A study of small cells with pyknosis-like nuclei in vaginal smears was made. Cytological specimens were obtained from the uterine cervix of patients (atrophic meno pause, severe dysplasia, carcinoma in situ and early in vasive carcinoma). In early invasive carcinoma, eosinophilic cells with pyknosis-like nuclei were found in all types of squamous epithel cells. But small cells (under 20μE in diameter) occupied the most part of eosinophilic cells with pyknosis-like nuclei in atrophic menopause. Polychromasia in small cells with pyknosis -like nuclei was most striking in early invasive carcinoma.
Generally, few eosinophilic cells with pyknosis -like nuclei were found in severe dysplasia or carcinoma in situ