1978 年 17 巻 1 号 p. 59-63
Clinically, it is often difficult to distinguish between a mucous carcinoma and a benign lesion of the breast. We have performed cytologic examinations of 6 cases of mucous carcinoma by aspiration cytology and of 2 cases by the use of nipple secretion (Both materials were used in one case)
Six out of 7 cases were cytologically positive, that is, cytologic examination was helpful in diagnosing these tumors.
All 7 cases were resected and histologically confirmed as mucous carcinoma. Among them, 4 cases were pure mucous carcinoma and those remaining were mixed with other types of carcinoma.
As the result of observation of cellular features of cytologic materials of these tumors, tumor cells most often appeared in solid clusters with clear evidence of distinct cell boundaries. The cytoplasm of tumor cells was abundant, anisokaryosis was slight, nuclei were usually small (8-10μ) and nuclear atypia was slight. A lesser degree of cellular atypism was generally found in pure mucous carcinoma compared with the mixed group.
The periodic-acid-Schiff reaction was performed by the use of cytologic material of 4 out of 7 cases. The cytologic picture of tumor cells surrounded by amorphous mucin was characteristic in 3 cases. Futhermore, signet-ring type cells with PAS-positive substances were rarely observed.