1978 年 17 巻 1 号 p. 89-94
It is considered infrequent to detect cancer cells in the vaginal or cervical smear in a case of ovarian cancer. Cancer cells were detected in the cervical smear and endometrial aspiration smear from a 60-year-old woman, who had last menstrual period 12 years ago. She complained of lower abdominal pain occasionally for about 1 year. Ovarian origin was suspected from morphology of the cancer cells which were extremely large, had prominent nucleoli, and had partially vacuolated cytoplasm.
Histopathological examination of the resected uterus, ovaries, and omentum showed the presence of papillary adenocarcinoma in bilateral ovaries, and metastasis was found in omentum and widespread in peritoneal surface and bowels, but not in the endometrium. Psammoma body which was not observed in the smear was proved in the histological section of the ovary. It was interpreted that the cancer cells in the cervical smear were carried through the tube and uterine cavity into the cervix from the ovary itself or peritoneal cavity. Cytohormonal study of this patient did not show a high estrogenic activity.