The Journal of the Japanese Society of Clinical Cytology
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
Cytological Analysis of Metastatic Adenocarcinoma of the Uterine Cervix
Toshiko JOBOHiroyuki KURAMOTOEiji OHNOTadaaki IMAIYoko ITOH
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1980 Volume 19 Issue 1 Pages 105-112


Metastatic carcinoma of the uterine cervix of extrapelvic origin is very rare. From our experience, however, the incidence of metastatic adenocarcinomas among metastie carcinomas of the cervix is as high as 26.1%.
The paper is to report seven cases of those carcinomas, of which six were originated in the stomach and a case in the sigmoid colon. The histology of 3 cases of gastric origin showed signet-ring cell carcinomas and the remaining 3 were tubular adenocarcinomas.
Cytologically, average sizes of cells (17.0-10.9) and nuclei (10.3-7.77) which have been metastasized from a gastrid carcinoma are smaller than those of the primary carcinoma respectively. The number of nucleoli in the carcinomas of gastric origin is 1 or 2 which are fewer than that in the primary carcinoma. Appearance of signet-ring cells in cytology is undoubtedly characteristic of the tumor of the same histology type and is observed in 10-20% of tumor cells calculated on the scattered cell area, whereas in the cases of tubular adenocarcinomas, signet-ring cells appear only exceptionally (0.7-6.4%). Clusterization, although not prominent, is still seen in. both types of gastric carcinomas, but the grape formation, honeycomb pattern, and pallisading pattern are rarely observed.
In the case of the carcinoma from the sigmoid colon, the cells are high-columnar with abundant cytoplasm. Their nucleoli resemble those of the primary adenocarcinoma in number. Pallisading pattern which consists of highcolumnar cells is most striking findings in this case.
The clinical findings reveal that the average age of patients in 7 cases was 38.1 years and most of the cases developed abnormal genital bleeding as a chief complaint with ovarian enlargement.
The significance of the metastatic adenocarcinoma of extragenital origin on a routine cytological survey of the cervix is emphasized, if adenocarcinomas of the cervix uteri are seen in young patients associated with a mass in the ovary. Clinical and cytological findings of the neoplasm are also discussed in comparison with the review of the literature.

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