Abstract
A rare case of primary villoglandular adenocarcinoma (VGA) of the uterine cervix is reported, particularly with regard to cytological findings. The patient was a 30-yearold primigravida-primipara. She consulted our Department of Obstetrics and Gynecology, complaining of lower abdominal pain and low back pain. Small papillary lesions were noted in the neck of the uterus. The colposcopic findings were similar. Scraping smear cytology of the neck of the uterus and cervical canal revealed relatively small glandular cells in a slightly irregular two-dimensional arrangement. Chromatin was thin, and nucleoli were not conspicuous. Aggregates of large cells constituting a large number of ducts that showed irregular projections and bifurcations were noted in one area of the specimen, suggesting early cervical adenocarcinoma. Histological examination of biopsy specimens revealed tall papillary or villous structures, and a diagnosis of VGA was made.
Adenocarcinoma in situ was noted in three of 12 cone biopsy specimens. The histopathology of VGA has been described in more than 40 cases worldwide, but, to our knowledge, this is the first cytological report of the disease in Japan.
