蛋白融解酵素洗浄法による胃癌の細胞診

特に良性異型細胞の形態とその発生母地について

抄録

During 1956 to 1967, cytodiagnosis was carried out for malignant and benign gastric lesions by the following various methods; the proteolytic enzyme lavage method, the selective proteolytic enzyme lavage method under fluoroscopy and the lavage method under fibergastroscopic observation.
The cases examined consist of 351 gastric can cers and 1119 benign gastric diseases. In 1119 be nign cases, the accuracy of the cytodiagnosis was 97, 2% Of 351 cancer cases, 288 cases (82%) was diagnosed cytologically as malignant, while 15 cases of benign gastric lesions were diagnosed as“suspicious” (Class 111) or “false positive”. In the present study, the cellular pictures of 3000 benign atypical cells obtained from above suspi cious or false positive cases were analysed morphologically.
The general features of the gastric benign atypical cells observed in the specimens (hemato xyline eosin stainning) were as follows; anisocy tosis, mutual inclusion, increase of nucleocyto plasmic ratio, thick and smooth nuclear mem brane, dominant nucleolus, multinucleolus, poor nuclear substance, redness of nucleolus, slightly irregular aggregation of chromatin, etc.
Among them, the most characteristic pictures of the benign atypical cells are found to be sm ooth and thick nuclear membrane and poor nucl ear substances, but rare abnormal aggregation of chromatin.
However, no definite differences were found in the morphology of nucleolus between benign at ypical cells and cancer cells. The frequencies in the appearance of the above morphological characteristics were demonstrated in detail.
In addition, the histopathological backgrounds for the above benign atypical cells were analysed by examining the gastric mucosa of each corres ponding cases.
The characteristic benign atypical cells were found presumably to exfoliate from the regener ative epithelium of chronic ulceration and the so-called atypical epithelial foci of the gastri mucosa in chronic gastritis.