Journal of Japan Society of Pain Clinicians
Online ISSN : 1884-1791
Print ISSN : 1340-4903
ISSN-L : 1340-4903
Examination of precipitation and sedimentation in quantity-restricted cold aqueous suspensions of granular Japanese herbal extracts commonly used during palliative and supportive care
Yuriko MATSUOKAMiho NAKANISHI
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2019 Volume 26 Issue 4 Pages 297-302

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Abstract

Purpose: To ensure controlled dosage of Japanese herbal medicines given in small quantities of water, sedimentation must be minimized. When anorexia or nausea are present, medicinal-extract suspensions in cold water are consumed more easily; finding no reports on this, we examined how sedimentation of different medications varied in icy-cold to lukewarm water. Method: Into separate 20 ml syringes, each containing 15 ml of distilled water at either 0℃, 20℃ or 40℃, we dropped half a sachet of each of 24 types of herbal extract granules. At just after and 5 min after suspension, the samples were agitated for 1 min; at 10 min after suspension, sedimentation was measured. Results: At 0℃ and 20℃, nine formulations showed no more sedimentation than at 40℃; of these, one had no macroscopic sedimentation at any sampling temperature. Conclusion: Some Japanese herbal formulations may be effectively administered in cool and cold water.

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© 2019 Japan Society of Pain Clinicians
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