In general lymphangioma, if infected, may have a specific feature of swelling. We have experienced two cases of retroperitoneal lymphangioma which showed positive inflammatory findings by laboratory work-up. In one case, a one-year-old girl, lymphangioma was found attached medially to the ascending colon, and in another case, a four-year-old boy, it was found in the retroperitoneal space near the pancreatic tail. By antibiotherapy the tumors both subsided in size, to a great extent in the former case, and to some extent in the latter case. Large retroperitoneal lymphangiomas being reduced in size, the operative maneuvers were rather simple, and complete removal of lymphangiomas could be accomplished.