先天性胆道閉塞症における抗生物質の胆汁内移行よりみた肝臓機能について
1981 年 17 巻 1 号 p. 31-35
詳細
1981 年 17 巻 1 号 p. 31-35
Biological activities of SB-PC against pseudomonas aeruginosa in bile were determined by the serial dilution method in 11 cases of biliary atresia 10 to 14 days after the operation and in 4 who were doing well without jaundice, 3 to 4 years after operation. The results were compared with those of adults (control group). The changes in concentration of SB-PC in serum in biliary atresia were similar to those in the control group. The concentration of SB-PC in bile was always higher than that in serum, and the highest level of the SB-PC in bile was 1, 705μg/ml in the control group. It was, however, very low and lower than 100μg/ml in biliary atresia in the early postoperative period inspite of good excretion of bile. SB-PC level in bile was about 3 times higher after 3 or 4 years after the operation comparing with that in the early postoperative period, but still lower than that of the control group.
