アドリアマイシン肝動注時の臓器組織内濃度に関する実験的研究 : 血中及び肝組織内濃度を指標とした至適投与法,投与量に対する一考察

抄録

Optimal method of administration and appropriate dosage for the malignant liver tumor of childhood were investigated by following method. Part 1. Dicision of the optimal method of adriamycin (ADM) administration for the malignant liver tumor. The mongrel dogs weighning 10-15 kg were divided in 4 groups according to the method of administration as follows : Group 1. one shot infusion of the ADM (0.2mg/kg) via hepatic artery. (N=10) Group 2. continuous (30 min) infusion of the ADM (0.2 mg/kg) via hepatic artery. (N = 10) Group 3. one shot infusion of the ADM (0.2 mg/kg) via peripheral vein. (N = 10) Group 4. continuous (30 min) infusion of the ADM (0.2 mg/kg) via peripheral vein. (N = 10) Among those 4 groups, the group 1 showed the highest ADM concentration in the hepatic tissue. (1.5X). On the otherhand, concentration of the ADM in the cardiac muscle or leakage to the peripheral blood of the group 1 showed extremly lower level (1/5) compared with other groups. Part 2. Dicision of the appropriate ADM dosage for one shot hepatic arterial infusion. The ADM tissue consentration levels following various (0.07 mg/kg, 0.1 mg/kg, 0.14 mg/kg) of ADM hepatic arterial infusion were compared with the tissue concentration level of ADM administered systemically in standard dose (0. 2 mg/kg). Consequently the group of ADM 0.1 mg/kg arterial infusion and systemic ADM administration group were shown almost the same hepatic tissue concentration level. Those results suggested that; 1. ADM one shot arterial infusion is the most effective for the malignant tiver tumor chemotherapy. 2. Arterial infusion chemotherapy can reduce its side effect. 3. Arterial infusion of ADM can reduce its dosage without reducing its effect.