カテーテル留置による胎仔腹腔内アルブミン投与の基礎的研究 : 非免疫性胎児水腫の胎児治療の試み

抄録

To examine a method of the intraperitoneal administration of albumin for intrauterine treatment of nonimmunologic hydrops fetalis, fetal rabbits were used and albumin was administered to them with a catheter inserted in the fetal peritoneal cavity. The efficacy and safety of this method of administration were studied. Intrauterine surgery to introduce a silicone catheter into the fetal peritoneal cavity was performed on the 27th day of pregnancy in nine rabbits. This procedure was followed by the administration of 80mg of rabbit albumin for four days. After the administration on the 31st day of pregnancy, the fetuses were recoverd by Caesarean section or by vaginal delivery. Examinations of the fetuses with the indwelling catheter revealed no premature delivery or fetal hypoplasia and showed that the albumin-treated group had a significant increase in serum albumin level over the control group. By using another four pregnant rabbits measurements were made of fetal circulating blood volume of five fetuses by the dye dilution method. The results showed that after the administration of albumin for four days, the total dose administered in the fetal peritoneal cavity (320mg of albumin) finally produced an increase of 8.4% in the serum level of albumin in the fetal circulating blood. These results suggested that the administration of albumin by way of an inserted catheter is an effective method to increase the serum level of a albumin in the fetus.