Two cases of necrotizing enterocolitis (NEC) after protracted diarrhea were presented. A 27-day-old boy showed gangrenous ileum with multiple ulcer at laparotomy and was died of septic shock 4 days after the resection of ileum and fashioning of enterostomy. A 79-day-old boy, who developed ileal gangrene with multiple ulcer, underwent the end-to-end anastomosis with the resection of the ileal lesion. Four days after the surgery, he had a perforation near the anastomotic site but survived by the exteriorization of the lesion. Histological findings of the resected ileum from both cases were identical to those observed in premature infant with NEC except for the absence of pneumatosis intestinalis. In literatures, most of NEC developed in the older infants and children after a protracted period of diarrhea or gastroenteritis indicated poor prognosis. The early recognition and subsequent therapy should decrease the mortality of NEC in this age group as samely as in neonates.
