Postoperative courses of eleven splenectomized children who suffered from idiopathic thrombocytopenic purpura, hereditary spherocytosis, hemolytic anemia, Hodgkin's disease and idiopathic portal hypertension were followed up for 1-13 years after splenectomy. Although no death from infectious desease occurred, severe infectious episodes including fulminant hepatitis, pyothorax, DIG or meningitis were experienced by the children who did not get prophylactic antiinfectious treatment during these periods. A case of hereditary spherocytosis encountered streptococcus infection after terminating two year medication of vicilin G. Oral intake of Bacta 1g/day or vicilin G 500,000 unit/day for more than 2 years after splenectomy are considered reasonable as prophylactic medication to avoid severe infection.
