Intraarterial injection of anticancer agents with lipiodol has been recently performed widely or hepatoma in adult patients and the remarkable therapeutic effects have been reporeted. An infant with hepatoblastoma was tereated by extended right hepatic lobectomy combined with intraarterial administration of several anticancer agents with lipiodol, pre- and post-operatively. Soon after these treatments he showed severe liver dysfunction, which made the chemotherapy discontinued. Pathohistologically the ballooning degeneration of the hepatic cells was characteristic. Thereafter his liver function has gradually recovered, though associated with severe portal hypertension. He has no obvious sign for tumor reccurence. Intraarterial administration of anticancer agents with lipiodol has been reported to be associated with few major side effect, but in some cases it may cause severe liver damage.
