Abstract
This paper documented a two-month-old girl with malignant rhabdoid tumor of the left kindney (MRTK) After total tumor excision, she was treated with radiotherapy and various kinds of anti-cancer drugs. Although mitomycin C and vincristine were partially effective, she died of the tumor growth eleven months after the onset of the disease. The surgical specimens and the cell line, established from the relapsed tumor, were analyzed using a panel of monoclonal antibodies bound with cytoskeletal proteins. The primary tumor was positive for neurofilament of neurogenic marker and vimentin of mesenchymal marker. The cell line was positive for neurofilament, vimentin and α-somooth muscle actin of myogenic marker. That suggests these results indicates this tumor has multiphenotypical divrsity or heterogeneity. Furthermore, fourteen cases of MRTK reported in Japanese literatures were reviewed. Most of cases involved infants under six months old. The prognosis was extremely poor, deu to the rapid tumor growth and multiple metastases.
