1990 Volume 12 Issue 5 Pages 467-473
Eleven adult mongrel dogs were injected fibrin glue mixing with X-ray contrast agent (Hytrast) to those unilateral lobar bronchi. Three of them were observed by chest-X ray and a bronchoscope, and eight of them were pathologically examined. From the chest X-ray and bronchoscopical examination, fibrin glue in the proximal large bronchi disappeared within 3 days after fibrin glue injection. and one of peripheral lung did within 7 days after fibrin glue injection. In this period temporary atelectasis were observed in these lobes. From the pathological examination, fibrin glue disappeared in the lobe a week after fibrin glue injection. In each two lobes one and two weeks after the injection, organizing pneumonia were found here and there in different degrees, which caused by fibrin glue. In two lobes four weeks after the injection, focal fibrosis areas were found as the result of the inflammation. It was concluded that in the method of the embolization of the bronchus related to the air leak by fibrin glue, not only bronchial obstructing function by injected fibrin glue but also the inflammation caused by it in the peripheral lung area participated in the healing of the air leak.
