Abstract
From October 2003 to May 2004, we conducted a detailed investigation on the use of a New AutoFluorescence Imaging (AFI) bronchovideoscope system: combined fluorescence-two reflectance imaging in the detection of early lung cancer and bronchial dysplasia. AFI consists of three signals which are an autofluorescence (460-690 nm) on excitation blue light (395-445nm) and two different bands of reflected light; G' (550nm) and R' (610nm). A total of 75 patients with suspected or known lung cancer were entered into this study. WLB and AFI detected 43 lesions, which consisted of lung cancers (n=12), squamous dysplasia (n=12), epipharynx carcinoma (N=1 ) and others (n=18) . The sensitivities of detecting cancer and dysplasia by WLB and AFI were 92% (23/25) and 96% (24/25) , respectively. And the specificity of AFI (66.6%) was higher than that of LIFE (38.8%). We conclude that AFI appears to be a signfficant advance in distimguishing preinvasive and malignant lesions from bronchitis.
