2020 Volume 42 Issue 4 Pages 343-348
Background. Malignant lymphoma occasionally presents with opacities in the pulmonary parenchyma; however, this condition might be difficult to diagnose using a transbronchial lung biopsy. Case. A 44-year-old woman received chemotherapy for peripheral T cell lymphoma, not otherwise specified, at 42 years old. She remained in remission for two years, after which she developed wet cough, and chest computed tomography revealed right lower lobe consolidation. Her condition did not improve despite antibiotic administration, and she was referred to our hospital for further management. We performed an endobronchial ultrasound-guided transbronchial biopsy using guide sheath with a concurrent cryobiopsy and obtained specimens from the right B8a. A histopathological examination showed tumor cells within the necrosis only in specimens obtained by a cryobiopsy. On an immunohistochemical examination, we observed cells that were immunopositive for CD3 and Epstein-Barr virus-encoded small RNA-in situ hybridization, leading to the diagnosis of relapsed T cell lymphoma. Therefore, she was transferred to the department of hematology for chemotherapy. Conclusion. We describe a patient diagnosed with relapsed T cell lymphoma based on cryobiopsy findings.
