The Journal of the Japan Society for Respiratory Endoscopy
Online ISSN : 2186-0149
Print ISSN : 0287-2137
ISSN-L : 0287-2137
Measurement of Leukotrienes in Broncho-alveolar Lavage Fluid from Patients with Various Pulmonary Diseases
Satoshi KitamuraYoko IshiharaFusayo Wagai[in Japanese][in Japanese][in Japanese][in Japanese]
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1985 Volume 7 Issue 1 Pages 22-26

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Abstract

In the present investigation we detected, identified and measured various leukotrienes (LTs) in broncho-alveolar lavage fluid (BALF) from patients with various pulmonary diseases and healthy controls by means of high performance liquid chromatography (HPLC) and by a tissue bioassay method using guinea pig ileum. 1) LTC_4, LTD_4 and LTE_4 were not detected in BALF from healthy volunteers. 2) In case of chronic bronchitis LTC_4 and LTD_4 were elevated, and total amounts of LTs were elevated in 9 of 15 patients. 3) In deffuse panbronchiolitis (DPB) LTC_4 and LTD_4 were elevated in 3 of 4 patients. 4) In cases of sarcoidosis, total amounts of LTs were elevated in 3 of 6 patients. 5) In cases of primary lung cancer LTC_4, LTD_4 and LTE_4 were elevated, and total amounts of LTs were elevated in 9 of 13 patients. 6) In cases of bronchiectasis total amounts of LTs were elevated in 5 of 9 patients. The above results suggest that LTs may play very important roles in the pathophysiology of chronic bronchitis, DPB, sarcoidosis, primary lung cancer and bronchiectasis.

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© 1985 The Japan Society for Respiratory Endoscopy
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