The Journal of the Japan Society for Respiratory Endoscopy
Online ISSN : 2186-0149
Print ISSN : 0287-2137
ISSN-L : 0287-2137
Effect of Supernatant of Sputum from Patients with Bronchial Asthma or Chronic Bronchial Infection on Ciliary Beat Frequency
Mitsuko KondoTakao Takizawa
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1987 Volume 9 Issue 2 Pages 115-121


Sputum from patients with bronchial asthma or chronic bronchial infection, was centrifuged and the supernatant was obtained. It was, then, applied to frog palate mucous membranes and ciliary beat frequency was measured using the microphoto-oscillation method. Slurry sputum from asthmatics suppressed ciliary beat. However, the cilia recovered their normal beat frequency after washing off the supernatant with medium-199. Neither mucoid sputum from asthmatics nor purulent sputum from cases of chonic bronchial infection suppressed the beat. Moreover, the beat frequency was independent of the viscosity and pH of the supernatant. We conclude that slurry sputum has a viscosity and pH-independent cilia beat suppressing factor.

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© 1987 The Japan Society for Respiratory Endoscopy
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