日本血栓止血学会誌
Online ISSN : 1880-8808
Print ISSN : 0915-7441
ISSN-L : 0915-7441
原 著
血友病犬コロニーにおける血友病A保因犬の診断
織  順一田中 一郎窪田 容子松本 智子神末 政樹柴田  優嶋  緑倫David LILLICRAP吉岡  章
著者情報
ジャーナル フリー

2002 年 13 巻 3 号 p. 252-258

詳細
抄録

Hemophilic dogs have an identical inheritance pattern and bleeding symptoms to human hemophilia A and therefore are a most suitable animal model of the human disease. The probability based on the pedigree data and the measurement of factor VIII coagulant activity (FVIII : C) have been used for carrier detection of canine hemophilia A. In order to improve the precision of carrier diagnosis, a ratio of FVIII : C to von Willebrand factor antigen (VWF : Ag) was used for the assessment of carrier status of canine hemophilia A. Two beagle dogs suspected to be hemophilic carriers by the reduction of FVIII : C to around 50 U/dl were tested for the ratio of FVIII : C/VWF : Ag. They were mated with a normal male beagle, and newborn puppies were tested for coagulation assays. One dog strongly suspected of being a carrier by the ratio was confirmed as a definite carrier by the production of a hemophilic puppy, which may be the first hemophilic dog in Japan resulting from a planned mating. The other dog suspected not to be a carrier by the ratio has never produced any hemophilic puppies. These findings suggest that the FVIII : C/VWF : Ag assessment is more reliable than FVIII : C alone for carrier detection of canine hemophilia A and is useful in the establishment of a canine hemophilic colony.

著者関連情報
© 2002 日本血栓止血学会
前の記事 次の記事
feedback
Top