Studies on characteristics of active prothrombin complex (Factor VIII inhibitor by-passing activity: FEIBA)

Abstract

Characteristics of active prothrombin complex (Factor VIII inhibitor by-passing activity: FEIBA) was investigated from viewpoint of blood coagulation.
Results are as follows:
(1) FEIBA (100units/ml) showed procoagulant activity of factors II (prothrombin), VII, IX and X. The existence of factor Xa and thrombin was also observed in its preparation. Prothrombin in its preparation was activated to thrombin with thromboplastin-calcium solution and in 2.5 molar glycine solution.
(2) FEIBA showed correcting power of coagulation disorders of factor VIII inhibitor plasma.
(3) Infusion of 50 units of FEIBA made rabbits died from occurrence of DIC.