It is well known that FDP appears in urine of patients with glomerulonephritis. To clarify the problem of whether urinary FDP arises from the lysis of the glomerular fibrin deposits or by filtration of fibrinogen and FDP from the plasma, we have studied the presence of D-dimer in serum and urine from patients with various renal disease.
FDP from plasma and urine was isolated by chromatography using small columns of activated Sepharose 4-B coupled with antifibrinogen Serum, and analysed by SDS-polyacrylamide gel electrophoresis.
1. D-dimers in urine were found in 13 of 26 cases and those in plasma in 5 of 15 cases.
2. Cases with positive urinary D-dimer had higher levels of urinary FDP, proteinuria, micro hematuria and severe renal dysfunction in comparison with cases with negative urinary D-dimer.
3. Ratio of D-dimer to monomer in urinary FDP was about 10 times more than in serum FDP. On the basis of this data, it may be suggested that there is intraglomerular fibrinolysis in cases with positive urinary D-dimer.