The effects of various drugs on experimental DIC induced by endotoxin infusion in rabbits were studied. The fibrin deposition rate and mortality were 50% and 33% in control (endotoxin alone) group. Heparin and hydrocortisone phosphate reduced both fibrin deposition (25%, 11%) and mortality (14%, 8%). Increase of fibrin deposition was observed by aprotinin (93%) and noradrenaline (91%), however, mortality was not changed (36%, 30%) as compared with control group. Fibrin deposition did not change by conjugated estrogen, however, mortality was reduced significantly (0%).
Theoretically, it seems that increase in fibrin deposition may produce high mortality. However, there was no pararellism between them as in aprotinin, noradenaline and conjugated estrogen groups. These drugs were capable of inhibiting activity on capillary permeability.