Abstract
In this study, the effectiveness of various drugs affecting the arachidonate cascade such as OP-4148, a derivative of PGI2, aspirin (ASA), an inhibitor of cyclooxygenase, OKY-046, an inhibitor of thromboxane (TX) synthetase and CV-3988, an antagonist against Platelet Activating Factor (PAF) were determined in animal experiments using rabbits along with a study on the relationship between changes in platelet and the renal function after burn injuries. A third degree burn of 35% of the total body surface area was prepared by immersing the back of rabbits in 80°C hot water, and the effectiveness of OP-41483, ASA, OKY-046 and CV-3988 was studied. In no therapy group, all rabbits died after 8 hours or more. Renal function tests in this group showed a decrease in creatinine clearance and an increase in FENa and CH2O. Such changes were improved slightly with infusion therapy, With OP-41483, OKY-046 and ASA, distinct improvement was observed (in order of extent of improvement), but with CV-3988 improvement was rather small. Resultantly, those drugs may also effective to prevent the organ failure after burn injury clinically.
