In our country, the various hemostatic medicines have been used after the operation. On the contrary, in Europe and USA, the anticoagulent medicines have been used before and after operation, because of the high incidence of the complications of deep vein thrombosis and pulmonary infarction after operation. So we made inquireies about how to use them in 566 main surgical facilities in Japan.
On the results, in the above of half surgical departments these medicines have usually been used yet, but in 17% of surgery, 9.5% of obsterics and gynecology and 29.4% of orthopedics, they have never been used at all. On surgery, in 42% of cardiovascular, 32.1% of respiratory and 10.8% of general surgery, they have not been used absolutely. For the patients with liver cirrhosis, obstructive jaundice and the massive transfusion on the operation, in over the 80% of facilities the hemostatic medicines have been used.
The using medicines are usually adrenochrome, anti-plasmin, vitamin K, the conjugated estrogens and hemocoagulase etc.
We have pointed out that there are no necessity to use the hemostatic medicines on the operation, because of hyper-coagulatic state, hypo-fibrinolytic state of blood, hyper function of platelet and high viscosity of blood after the operation, especially on the cancer operation. Also we investigated how difference of the volume of bleeding and hemorrhagic complications after operation were between in the groups of using the hemostatic medicines and no using them. No significant difference was between using and no using. Therefore, we issue the warning to against the various hemostatic medicines after the operation.