抄録
It is suggested that low production of PGI2 by endothelial cells is one of the aggravating factors in toxemia of pregnancy (TOX). Therefore, we investigated whether phospholipase A2 (PLA2) activity, which released arachidonic acid (A. A.) from cell membrane, influenced PGI2 production in TOX.
(1) Conversion volume from phosphatidyl choline to A. A. in normal pregnancy (NOR) was more than in mild and severe TOX, but no significant difference was shown between them.
(2) The Vmax value (×10-10M/mg protein: mean±S. E.) for PLA2 in NOR (10.2±1.6) was significantly higher than in mild (3.5±0.3) and severe (3.8±1.2) TOX (p<0.05).
(3) The Km value (×10-7M: mean±S. E.) for PLA2 in NOR (2.6±0.4) was significantly higher than in mild (1.2±0.2) and severe (0.8±0.3) TOX (p<0.05).
It was concluded that A. A. supply in severe TOX was significantly less than in NOR, and that reduced A. A. supply was one of the aggravating factors in low production of PGI2 in severe TOX.
