1989 Volume 20 Issue 6 Pages 524-529
Effect of prostaglandin E1 on blood loss from polytetrafluoroethylene (PTFE) graft was studied in an animal model. After the abdominal aorta of rabbits was replaced with PTFE graft, it was punctured with a straight needle (120μm in diameter) under systemic heparinization (50U/kg). Blood pressure, blood loss from the puncture site, and bleeding time were measured in various concentrations. Then the luminal surfaces of PTFE graft around puncture sites were analyzed by scanning electron microscopy (SEM). Various concentrations of PGE1 (0, 0.05, 0.1, 0.2μg/kg/min) was continuously infused via ear vein after the bolus intravenous injection of heparin (50U/kg). Although there were no changes in systemic blood pressure, bleeding time and blood loss were increased significantly by PGE1 administration (0.1 and 0.2μg/kg/min) in comparison to the control (heparin alone). SEM revealed that the hemostatic plug formation at the puncture site was suppressed by PGE1 in a dose dependent manner.
These results indicate that PGE1 administration should be avoid or used with a low dose in vascular reconstruction using prosthesis, especially mode of PTFE.