In our laboratory, we have studied the morphological changes of various kinds of blood vessels following administration of soluble immune complexes.
After administration of various soluble immune complexs, acute glomerulonephritis in kidney and pulmonary fibrosis occured. In bone and bone marrow, as reported in several previous papers, administration of soluble immune complexes led to general morphological changes in the arterial wall resulting in arteritis. The most characteristic morphological changes seen in the bone marrow were the capillarisation of the sinusoidal endothelia with luminal distension and a severe degree of plasma stasis in the lumina.
With the repeated administration of soluble immune complexes, we observed the formation of micro-abscesses which might developed into osteomyelitis.
In this paper, the formative processes of osteomyelitis will be discussed in relation to Aschoff's definition of inflammation. We will emphasize the importance of the capillarisation of the sinusoidal endothelia for the formation of osteomyelitis.