Experimental studies of factors regulating fibrinogen

Abstract

We studied experimentally factors of regulating fibrinogen in rat.
Result: Liver cirrhosis induced by CCl₄ decreased fibrinogen of plasma.
Subcutaneous transplantation of Bacteria and tumor cells (AH130, AH 166F), I. V. injection of tumor cells and tumor extracts and injury of skin increased fibrinogen. But transplantation of egg albumin and i. v. injection of antiplasmin did not increased fibrinogen.
Increase of fibrinogen was inhibited by corticosteroid, but antihistamin agents had no effect.
Conclusion: as the result.
We suggested some inflammation stimulating fibrinogen production in liver, and the promoting factor is not related with histamin system, and corticosteroid inhibited this mechanism.