血栓性血小板減少性紫斑病と汎発性血管内凝固症候群における分子マーカーの比較

抄録

We have investigated the difference of the coagulo-fibrinolytic factors between 6 patients of thrombotic thrombocytopenic purpura (TTP) and 27 patients of disseminated intravascular coagulation (DIC) using some hemostatic molecular markers. The changes of coagulo-fibrinolytic factors containg a high level of fibrin-fibrinogen degradation products (FDP) were small in TTP patients. Though we found a significant increase of D-dimer FDP level and thrombin-antithrombin III complex (TAT) level except normal plasmin-α₂ plasmin inhibitor complex (PIC) level in TTP patients, these increases were much smaller than those of DIC patients. The tissue-type plasminogen activator (t-PA) level was equally high against normal level of urinary-type plasminogen activator (u-PA) in both patients with TTP and DIC, and there were three patients whose plasminogen activator inhibitor type-1 (PAI-1) was much higher than those of DIC patients.
We found that the increase of hemostatic molecular makers (D-dimer FDP, TAT, PIC) in TTP patients was much smaller than in DIC patients.