各種膠原病患者におけるHCV抗体 (抗C100-3抗体), HCV-RNAの検討

抄録

Sera from patients with collagen diseases followed at Nagoya City University Hospital were investigated for the detection of antibody (C100-3) to hepatitis C virus (HCV), and HCV-RNA using the method of reverse transcriptase polymerase chain reaction (RT-PCR). The overall prevalance of HCV antibody positivity was 4.8% (12/252) in the patients, and significantly higher than that (1.1-1.2%) of Japanese populations of blood donors. Relative high prevalence (6.5%) was observed in patients with Sjogren's syndrome (SjS). Seven of 12 patients with anti-HCV antibodies were detected HCV-RNA in their sera. All of these patients, except one case, had chances of the infection for HCV. 5 patients, whose sera was negative result of HCV-RNA, had no history of HCV infection. Therefore, the presence of false-positive tests for anti-HCV antibodies was 2.0% (5/245) in patients with collagen diseases. Sera from patients with SjS showed the higher false-positive tests. The false-positive tests for antibodies to HCV did not correlate with the presence of antinuclear antibodies, rheumatoid factor, and hypergamma-globulinemia.