日本輸血学会雑誌
Online ISSN : 1883-8383
Print ISSN : 0546-1448
ISSN-L : 0546-1448
第2世代HCV抗体陽性献血者における各抗体の保有状況とHCV-RNAの検出
鈴木 典子伊藤 直文跡部 里香石川 晃一
著者情報
ジャーナル フリー

1993 年 39 巻 3 号 p. 563-568

詳細
抄録

We studied antibody response against three different recombinant antigens (5-1-1/c100-3, c33c, c22-3) by RIBAII and detection of HCV RNA by RT-PCR in serum samples of blood donors positive for anti-HCV by 2nd generation HCV antibody screening test (PHA).
In 52 serum samples showing PHA titer≥212, 37 samples (71%) were reactive to three different antigens (5-1-1/c100-3, c33c, c22-3), and other 15 samples (29%) were reactive to two different antigens (c33c, c22-3). Moreover, HCV RNA was detected in 51 samples (98%) by RT-PCR.
On the other hand, in 52 serum samples showing PHA titer 25-11, only one samples (2%) was reactive to three different antigens (5-1-1/c100-3, c33c, c22-3) and other 7 samples (13%) were reactive to two antigens (c33c, c22-3). Twenty-five samples (48%) were reactive only to core antigen (c22-3). HCV RNA was detected in 5 samples (10%) out of these 52 samples.
These results suggest that blood donors showing PHA titer≥212 are HCV carriers and the majority of blood donors showing PHA titer 25-11 may have past infection of HCV.

著者関連情報
© 日本輸血・細胞治療学会
前の記事 次の記事
feedback
Top