2000 年 46 巻 5 号 p. 463-466
Among the 21, 354 pregnant women studied, anti-HPA-4b was detected in 39 (0.18%), and 6 neonates developed neonatal alloimmune thrombocytopenia (NAIT; platelet count<15×104/μl). Platelet count at delivery was significantly different between neonates compatible (27.0×104/μl) and incompatible (15.3×104/μl, p<0.05) with maternal anti-HPA-4b. However, no significant difference between maternal anti-HPA-4b titer and the platelet count of incompatible neonates was observed. High titer (>64) of anti-HPA-4b, however, was associated with a higher risk of NAIT. In addition, normalization of platelet count (>15×104/μl) was delayed in babies from mothers with high antibody titer (>64) compared with babies from women with low antibody titer (≤64).