日本輸血学会雑誌
Online ISSN : 1883-8383
Print ISSN : 0546-1448
ISSN-L : 0546-1448
抗HPA-4b (Yuka) 抗体保有妊婦からの新生児血小板減少症発症についての予視的スタデイ
竹内 千華子大戸 斉山口 富子遠山 ゆり子山口 脩森田 庄治榎本 隆行半戸 啓一石島 あや子今村 真哉藤森 敬也菅藤 満高崎 克哲大杉 和雄吉松 宣弘佐藤 英二根元 公夫金 彰午吉田 孝雄吾妻 達郎佐藤 章
著者情報
ジャーナル フリー

2000 年 46 巻 5 号 p. 463-466

詳細
抄録

Among the 21, 354 pregnant women studied, anti-HPA-4b was detected in 39 (0.18%), and 6 neonates developed neonatal alloimmune thrombocytopenia (NAIT; platelet count<15×104l). Platelet count at delivery was significantly different between neonates compatible (27.0×104l) and incompatible (15.3×104l, p<0.05) with maternal anti-HPA-4b. However, no significant difference between maternal anti-HPA-4b titer and the platelet count of incompatible neonates was observed. High titer (>64) of anti-HPA-4b, however, was associated with a higher risk of NAIT. In addition, normalization of platelet count (>15×104l) was delayed in babies from mothers with high antibody titer (>64) compared with babies from women with low antibody titer (≤64).

著者関連情報
© 日本輸血・細胞治療学会
次の記事
feedback
Top