A nation-wide survey of 2903 clinical cases transfused with more than 1500ml a day in 115 hospitals, was made with regard to the occurrence of side effects, including latent transfusion reactions.
The rate of occurrence of side effects was proportional to the volume transfused with under 3, 000ml daily. This rate was increased in the massive transfusions exceeding 3, 000ml, which should be called “massive” transfusions because of its distinct character.
It has been seen that insufficient blood transfusions augmented the incidence of unfavorable reactions under massive bleeding.
Hemorrhagic tendency and other transfusion reactions seemed to be dependent on intrinsic factors of the recipients rather than extrinsic ones.