Abstract
Survivin is a member of the inhibitor of apoptosis protein (IAP) family and its usefulness as a tumor marker has been reported. In this study, we compared the accuracy of immunohistochemical analysis using survivin as a marker for tumor genesis and differentiation canine cutaneous lymphoma from lupus erythematosus (LE). The immunohistochemical analysis using polyclonal antibody against canine survivin was used to analyze expression in canine cutaneous lymphoma (19 cases) and lupus erythematosus (11 cases). Canine survivin expression was detected in all cases in the nuclei and cytoplasm in both groups. For both cutaneous lymphoma and LE, the difference in immunoractivity scores determined by positive-staining cells and intensity of survivin staining was not significant.
