Post-chemotherapy intestinal fibrotic stricture in a cat with high-grade intestinal lymphoma

a case report

Abstract

A 3-year-old castrated male cat was presented with lethargy, anorexia, and melena. A complete blood count revealed regenerative anemia. Abdominal ultrasonography revealed a layer-disrupted intestinal mass at the ileocecal junction. Fine needle aspiration performed on the mass revealed large lymphocytes, suggesting lymphoma. The patient was treated with CHOP-based chemotherapy but admitted for emergency care with vomiting and depression during the CHOP protocol. Abdominal ultrasonography suggested annular intestinal stricture at the site of lymphoma. The patient underwent ileocecectomy, which resolved the small intestinal obstruction. Histopathologic examination of the resected specimen demonstrated transmural enterotyphilitis with prominent fibrosis. The patient remained stable without relapse. To our knowledge, this is the first case of intestinal stricture occurring during chemotherapy for feline high-grade intestinal lymphoma.