低体温麻酔の癌転移形成促進機序に関する若干の知見

抄録

In previous reports, we could revealed that the metastatic incidence of tumor bearing animals following surgery under hypothermia was significantly enhanced,
The purpose of this reports is to clarify the mechanisms respon sible for the augmentation of metastatic incidence in tumor bearing animals following hypothermia
As a result, we could reveal that hypothermia caused the mutual adhesiveness of tumor cells to dissociate, and a tendency of tumorcells to stick more easily to vessel wessel walls. We have demonstrated that the incidence of tumor metastases following hypothermia may be augmented by increased numbers of circulating tumor cells, by alteration of host factors such as hypercoagulability and reticuloendothelial interference. In addition, alteration of blood oxygen concentration influence the development of metastases.