疼痛の成立機構に関する神経藥理学的研究

抄録

A study was made of the actions of various drugs on average evoked potential from the cerebral cortex, the brain stem reticular formation, CM and the hippocampus following stimulation of the sciatic nerve, intestines and uterus in rabbits.
I. Following stimulation of the sciatic nerve, intestines and the uterus, there appeared spike like negative response (N₁, N₂, N₃) followed by positive response (P) in the cerebral cortex.
2. Follo wing stimulation of the sciatic nerve, intestines and the uterus, there appeared spike like negative response (RN₁, CN₁, HN₁) follwed by slight curved negative response (RN₂, CN₂, HN₂) in the brain stem reticular formation, CM and the hippocampus.
3. Morphine chiefly inhibited N₁, RN₁, CN₁, HN₁, and HN₂; it eith er inhibited or accelerated N₂, N₃, P, RN₂ and CN₂. Thus it was led to assume that the afferent pathway consists of one nervous system which was related with the development of N₁, RN₁, and CN₁ and the other nervous system which was related with N₂, RN₂, and CN₂, the former system being responsible for the development of pain.
4. Barbiturate inhibited N₁, N₂, N₃, RN₂, CN₁, and HN₁, a ccelerated P. either inhibited or accelerated RN₁, CN₂, and HN₂. It characteristically inhibited RN₂ markedly. Therefore it was strongly suggested that the nervous system which was related with the development of RN₂ took part in the forming of consciousness.
5. Experiments with aminopyrine, chlorpromazine and myanesin as to average evoked potential revealed that these agents acted similarly on RN₁ and HN₂. The above data supported to conclude that the nervous system which was related with the development of HN₂ in the hippocampus might be responsible for the development of pain keeping a certain relationship with pain reaction.